DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (280-289)
- 280 Iron deficiency anemias
- Includes: anemia:
- asiderotic
- hypochromic-microcytic
- sideropenic
- Excludes: familial microcytic anemia (282.4)
- 280.0 Secondary to blood loss (chronic)
- Normocytic anemia due to blood loss
- Excludes: acute posthemorrhagic anemia (285.1)
- 280.1 Secondary to inadequate dietary iron intake
- 280.8 Other specified iron deficiency anemias
- Paterson-Kelly syndrome
- Plummer-Vinson syndrome
- Sideropenic dysphagia
- 280.9 Iron deficiency anemia, unspecified
- Anemia:
- achlorhydric
- chlorotic
- idiopathic hypochromic
- iron [Fe] deficiency NOS
- 281 Other deficiency anemias
- 281.0 Pernicious anemia
- Anemia:
- Addison's
- Biermer's
- congenital pernicious
- Congenital intrinsic factor [Castle's] deficiency
- Excludes: combined system disease without mention of anemia (266.2)
- subacute degeneration of spinal cord without mention of anemia (266.2)
- 281.1 Other vitamin B12 deficiency anemia
- Anemia:
- vegan's
- vitamin B12 deficiency (dietary)
- due to selective vitamin B12 malabsorption with proteinuria
- Syndrome:
- Imerslund's
- Imerslund-Gräsbeck
- Excludes: combined system disease without mention of anemia (266.2)
- subacute degeneration of spinal cord without mention of anemia (266.2)
- 281.2 Folate-deficiency anemia
- Congenital folate malabsorption
- Folate or folic acid deficiency anemia:
- Goat's milk anemia
- Nutritional megaloblastic anemia (of infancy)
- Use additional E code to identify drug
- 281.3 Other specified megaloblastic anemias, not elsewhere classified
- Combined B12 and folate-deficiency anemia
- Refractory megaloblastic anemia
- 281.4 Protein-deficiency anemia
- Amino-acid-deficiency anemia
- 281.8 Anemia associated with other specified nutritional deficiency
- 281.9 Unspecified deficiency anemia
- Anemia:
- dimorphic
- macrocytic
- megaloblastic NOS
- nutritional NOS
- simple chronic
- 282 Hereditary hemolytic anemias
- 282.0 Hereditary spherocytosis
- Acholuric (familial) jaundice
- Congenital hemolytic anemia (spherocytic)
- Congenital spherocytosis
- Minkowski-Chauffard syndrome
- Spherocytosis (familial)
- Excludes: hemolytic anemia of newborn (773.0-773.5)
- 282.1 Hereditary elliptocytosis
- Elliptocytosis (congenital)
- Ovalocytosis (congenital) (hereditary)
- 282.2 Anemias due to disorders of glutathione metabolism
- Anemia:
- 6-phosphogluconic dehydrogenase deficiency
- enzyme deficiency, drug-induced
- erythrocytic glutathione deficiency
- glucose-6-phosphate dehydrogenase [G-6-PD] deficiency
- glutathione-reductase deficiency
- hemolytic nonspherocytic (hereditary), type I
- Disorder of pentose phosphate pathway
- Favism
- 282.3 Other hemolytic anemias due to enzyme deficiency
- Anemia:
- hemolytic nonspherocytic (hereditary), type II
- hexokinase deficiency
- pyruvate kinase [PK] deficiency
- triosephosphate isomerase deficiency
- 282.4 Thalassemias
- Cooley's anemia
- Hereditary leptocytosis
- Mediterranean anemia (with other hemoglobinopathy)
- Microdrepanocytosis
- Sickle-cell thalassemia
- Thalassemia (alpha) (beta) (intermedia) (major) (minima) (minor) (mixed) (trait) (with other hemoglobinopathy)
- Thalassemia-Hb-S disease
- Excludes: sickle-cell:
- anemia (282.60-282.69)
- trait (282.5)
- 282.5 Sickle-cell trait
- Hb-AS genotype
- Hemoglobin S [Hb-S] trait
- Heterozygous:
- Excludes: that with other hemoglobinopathy (282.60-282.69)
- that with thalassemia (282.4)
- 282.6 Sickle-cell anemia
- Excludes: sickle-cell thalassemia (282.4)
- sickle-cell trait (282.5)
- 282.60 Sickle-cell anemia, unspecified
- 282.61 Hb-S disease without mention of crisis
- 282.62 Hb-S disease with mention of crisis
- 282.63 Sickle-cell/Hb-C disease
- 282.69 Other
- Disease:
- Hb-S/Hb-D
- Hb-S/Hb-E
- sickle-cell/Hb-D
- sickle-cell/Hb-E
- 282.7 Other hemoglobinopathies
- Abnormal hemoglobin NOS
- Congenital Heinz-body anemia
- Disease:
- Hb-Bart's
- hemoglobin C [Hb-C]
- hemoglobin D [Hb-D]
- hemoglobin E [Hb-E]
- hemoglobin Zurich [Hb-Zurich]
- Hemoglobinopathy NOS
- Hereditary persistence of fetal hemoglobin [HPFH]
- Unstable hemoglobin hemolytic disease
- Excludes: familial polycythemia (289.6)
- hemoglobin M [Hb-M] disease (289.7)
- high-oxygen-affinity hemoglobin (289.0)
- 282.8 Other specified hereditary hemolytic anemias
- 282.9 Hereditary hemolytic anemia, unspecified
- Hereditary hemolytic anemia NOS
- 283 Acquired hemolytic anemias
- 283.0 Autoimmune hemolytic anemias
- Autoimmune hemolytic disease (cold type) (warm type)
- Chronic cold hemagglutinin disease
- Cold agglutinin disease or hemoglobinuria
- Hemolytic anemia:
- cold type (secondary) (symptomatic)
- drug-induced
- warm type (secondary) (symptomatic)
- Use additional E code to identify cause, if drug-induced
- Excludes: Evans' syndrome (287.3)
- hemolytic disease of newborn (773.0-773.5)
- 283.1 Non-autoimmune hemolytic anemias
- 283.10 Non-autoimmune hemolytic anemia, unspecified
- 283.11 Hemolytic-uremic syndrome
- 283.19 Other non-autoimmune hemolytic anemias
- Hemolytic anemia:
- mechanical
- microangiopathic
- toxic
- Use additional E code to identify cause
- 283.2 Hemoglobinuria due to hemolysis from external causes
- Acute intravascular hemolysis
- Hemoglobinuria:
- from exertion
- march
- paroxysmal (cold) (nocturnal)
- due to other hemolysis
- Marchiafava-Micheli syndrome
- Use additional E code to identify cause
- 283.9 Acquired hemolytic anemia, unspecified
- Acquired hemolytic anemia NOS
- Chronic idiopathic hemolytic anemia
- 284 Aplastic anemia
- 284.0 Constitutional aplastic anemia
- Aplasia, (pure) red cell:
- congenital
- of infants
- primary
- Blackfan-Diamond syndrome
- Familial hypoplastic anemia
- Fanconi's anemia
- Pancytopenia with malformations
- 284.8 Other specified aplastic anemias
- Aplastic anemia (due to):
- chronic systemic disease
- drugs
- infection
- radiation
- toxic (paralytic)
- Pancytopenia (acquired)
- Red cell aplasia (acquired) (adult) (pure) (with thymoma)
- Use additional E code to identify cause
- 284.9 Aplastic anemia, unspecified
- Anemia:
- aplastic (idiopathic) NOS
- aregenerative
- hypoplastic NOS
- nonregenerative
- refractory
- Medullary hypoplasia
- 285 Other and unspecified anemias
- 285.0 Sideroblastic anemia
- Anemia:
- hypochromic with iron loading
- sideroachrestic
- sideroblastic
- acquired
- congenital
- hereditary
- primary
- refractory
- secondary (drug-induced) (due to disease)
- sex-linked hypochromic
- vitamin B6-responsive
- Pyridoxine-responsive (hypochromic) anemia
- Use additional E code to identify cause, if drug-induced
- 285.1 Acute posthemorrhagic anemia
- Anemia due to acute blood loss
- Excludes: anemia due to chronic blood loss (280.0)
- blood loss anemia NOS (280.0)
- 285.8 Other specified anemias
- Anemia:
- dyserythropoietic (congenital)
- dyshematopoietic (congenital)
- leukoerythroblastic
- von Jaksch's
- Infantile pseudoleukemia
- 285.9 Anemia, unspecified
- Anemia:
- NOS
- essential
- normocytic, not due to blood loss
- profound
- progressive
- secondary
- Oligocythemia
- Excludes: anemia (due to):
- blood loss:
- acute (285.1)
- chronic or unspecified (280.0)
- iron deficiency (280.0-280.9)
- 286 Coagulation defects
- 286.0 Congenital factor VIII disorder
- Antihemophilic globulin [AHG] deficiency
- Factor VIII (functional) deficiency
- Hemophilia:
- NOS
- A
- classical
- familial
- hereditary
- Subhemophilia
- Excludes: factor VIII deficiency with vascular defect (286.4)
- 286.1 Congenital factor IX disorder
- Christmas disease
- Deficiency:
- factor IX (functional)
- plasma thromboplastin component [PTC]
- Hemophilia B
- 286.2 Congenital factor XI deficiency
- Hemophilia C
- Plasma thromboplastin antecedent [PTA] deficiency
- Rosenthal's disease
- 286.3 Congenital deficiency of other clotting factors
- Congenital afibrinogenemia
- Deficiency:
- AC globulin factor:
- I [fibrinogen]
- II [prothrombin]
- V [labile]
- VII [stable]
- X [Stuart-Prower]
- XII [Hageman]
- XIII [fibrin stabilizing]
- Laki-Lorand factor
- proaccelerin
- Disease:
- Dysfibrinogenemia (congenital)
- Dysprothrombinemia (constitutional)
- Hypoproconvertinemia
- Hypoprothrombinemia (hereditary)
- Parahemophilia
- 286.4 von Willebrand's disease
- Angiohemophilia (A) (B)
- Constitutional thrombopathy
- Factor VIII deficiency with vascular defect
- Pseudohemophilia type B
- Vascular hemophilia
- von Willebrand's (-Jürgens') disease
- Excludes: factor VIII deficiency:
- NOS (286.0)
- with functional defect (286.0)
- hereditary capillary fragility (287.8)
- 286.5 Hemorrhagic disorder due to circulating anticoagulants
- Antithrombinemia
- Antithromboplastinemia
- Antithromboplastino-genemia
- Hyperheparinemia
- Increase in:
- anti-VIIIa
- anti-IXa
- anti-Xa
- anti-XIa
- antithrombin
- Systemic lupus erythematosus [SLE] inhibitor
- Use additional E code to identify cause, if drug-induced
- 286.6 Defibrination syndrome
- Afibrinogenemia, acquired
- Consumption coagulopathy
- Diffuse or disseminated intravascular coagulation [DIC syndrome]
- Fibrinolytic hemorrhage, acquired
- Hemorrhagic fibrinogenolysis
- Pathologic fibrinolysis
- Purpura:
- Excludes: that complicating:
- abortion (634-638 with .1, 639.1)
- pregnancy or the puerperium (641.3, 666.3)
- disseminated intravascular coagulation in newborn (776.2)
- 286.7 Acquired coagulation factor deficiency
- Deficiency of coagulation factor due to:
- liver disease
- vitamin K deficiency
- Hypoprothrombinemia, acquired
- Excludes: vitamin K deficiency of newborn (776.0)
- Use additional E-code to identify cause, if drug-induced
- 286.9 Other and unspecified coagulation defects
- Defective coagulation NOS
- Deficiency, coagulation factor NOS
- Delay, coagulation
- Disorder:
- Excludes: abnormal coagulation profile (790.92)
- hemorrhagic disease of newborn (776.0)
- that complicating:
- abortion (634-638 with .1, 639.1)
- pregnancy or the puerperium (641.3, 666.3)
- 287 Purpura and other hemorrhagic conditions
- Excludes: hemorrhagic thrombocythemia (238.7)
- purpura fulminans (286.6)
- 287.0 Allergic purpura
- Peliosis rheumatica
- Purpura:
- anaphylactoid
- autoimmune
- Henoch's
- nonthrombocytopenic:
- rheumatica
- Schönlein-Henoch
- vascular
- Vasculitis, allergic
- Excludes: hemorrhagic purpura (287.3)
- purpura annularis telangiectodes (709.1)
- 287.1 Qualitative platelet defects
- Thrombasthenia (hemorrhagic) (hereditary)
- Thrombocytasthenia
- Thrombocytopathy (dystrophic)
- Thrombopathy (Bernard-Soulier)
- Excludes: von Willebrand's disease (286.4)
- 287.2 Other nonthrombocytopenic purpuras
- 287.3 Primary thrombocytopenia
- Evans' syndrome
- Megakaryocytic hypoplasia
- Purpura, thrombocytopenic
- congenital
- hereditary
- idiopathic
- Thrombocytopenia:
- congenital
- hereditary
- primary
- Tidal platelet dysgenesis
- Excludes: thrombotic thrombocytopenic purpura (446.6)
- transient thrombocytopenia of newborn (776.1)
- 287.4 Secondary thrombocytopenia
- Posttransfusion purpura
- Thrombocytopenia (due to):
- dilutional
- drugs
- extracorporeal circulation of blood
- massive blood transfusion
- platelet alloimmunization
- Use additional E code to identify cause
- Excludes: transient thrombocytopenia of newborn (776.1)
- 287.5 Thrombocytopenia, unspecified
- 287.8 Other specified hemorrhagic conditions
- Capillary fragility (hereditary)
- Vascular pseudohemophilia
- 287.9 Unspecified hemorrhagic conditions
- Hemorrhagic diathesis (familial)
- 288 Diseases of white blood cells
- Excludes: leukemia (204.0-208.9)
- 288.0 Agranulocytosis
- Infantile genetic agranulocytosis
- Kostmann's syndrome
- Neutropenia:
- NOS
- cyclic
- drug-induced
- immune
- periodic
- toxic
- Neutropenic splenomegaly
- Use additional E code to identify drug or other cause
- Excludes: transitory neonatal neutropenia (776.7)
- 288.1 Functional disorders of polymorphonuclear neutrophils
- Chronic (childhood) granulomatous disease
- Congenital dysphagocytosis
- Job's syndrome
- Lipochrome histiocytosis (familial)
- Progressive septic granulomatosis
- 288.2 Genetic anomalies of leukocytes
- Anomaly (granulation) (granulocyte) or syndrome:
- Alder's (-Reilly)
- Chédiak-Steinbrinck (-Higashi)
- Jordan's
- May-Hegglin
- Pelger-Huet
- Hereditary:
- hypersegmentation
- hyposegmentation
- leukomelanopathy
- 288.3 Eosinophilia
- Eosinophilia
- allergic
- hereditary
- idiopathic
- secondary
- Eosinophilic leukocytosis
- Excludes: Löffler's syndrome (518.3)
- pulmonary eosinophilia (518.3)
- 288.8 Other specified disease of white blood cells
- Leukemoid reaction
- lymphocytic
- monocytic
- myelocytic
- Leukocytosis
- Lymphocytopenia
- Lymphocytosis (symptomatic)
- Lymphopenia
- Monocytosis (symptomatic)
- Plasmacytosis
- Excludes: immunity disorders (279.0-279.9)
- 288.9 Unspecified disease of white blood cells
- 289 Other diseases of blood and blood-forming organs
- 289.0 Polycythemia, secondary
- High-oxygen-affinity hemoglobin
- Polycythemia:
- acquired
- benign
- due to:
- fall in plasma volume
- high altitude
- emotional
- erythropoietin
- hypoxemic
- nephrogenous
- relative
- spurious
- stress
- Excludes: polycythemia:
- neonatal (776.4)
- primary (238.4)
- vera (238.4)
- 289.1 Chronic lymphadenitis
- Chronic:
- adenitis any lymph node, except mesenteric
- lymphadenitis any lymph node, except mesenteric
- Excludes: acute lymphadenitis (683)
- mesenteric (289.2)
- enlarged glands NOS (785.6)
- 289.2 Nonspecific mesenteric lymphadenitis
- Mesenteric lymphadenitis (acute) (chronic)
- 289.3 Lymphadenitis, unspecified, except mesenteric
- 289.4 Hypersplenism
- "Big spleen" syndrome
- Dyssplenism
- Hypersplenia
- Excludes: primary splenic neutropenia (288.0)
- 289.5 Other diseases of spleen
- 289.50 Disease of spleen, unspecified
- 289.51 Chronic congestive splenomegaly
- 289.59 Other
- Lien migrans
- Perisplenitis
- Splenic:
- abscess
- atrophy
- cyst
- fibrosis
- infarction
- rupture, nontraumatic
- Splenitis
- Wandering spleen
- Excludes: bilharzial splenic fibrosis (120.0-120.9)
- hepatolienal fibrosis (571.5)
- splenomegaly NOS (789.2)
- 289.6 Familial polycythemia
- Familial:
- benign polycythemia
- erythrocytosis
- 289.7 Methemoglobinemia
- Congenital NADH [DPNH]-methemoglobin-reductase deficiency
- Hemoglobin M [Hb-M] disease
- Methemoglobinemia:
- NOS
- acquired (with sulfhemoglobinemia)
- hereditary
- toxic
- Stokvis' disease
- Sulfhemoglobinemia
- Use additional E code to identify cause
- 289.8 Other specified diseases of blood and blood-forming organs
- Hypergammaglobulinemia
- Myelofibrosis
- Pseudocholinesterase deficiency
- 289.9 Unspecified diseases of blood and blood-forming organs
- Blood dyscrasia NOS
- Erythroid hyperplasia