The goal of
Biomedical Informatics Core (BIC) of the Northeast Biodefense Center is to establish
collaborations with the member scientists to meet
their increasing demand to deal with large and
complex genomic, proteomic, and clinical data in
their biomedical research. The BIC will
anticipate and rapidly provide services for
researchers to better understand pathogen biology,
pathogen-host interactions, and rational
therapeutic and vaccine design using cutting-edge
tools of informatics and computational biology.
The BIC also has an additional function to
educate potential users the power and limitations
of biomedical informatics technologies. For
example, the BIC hosts the Universal Virus
Database of the international Committee on
Taxonomy of Viruses (ICTVdb). The BIC is located at
Columbia University School of Medicine.
Contacts
as of 2006-present:
• Aris Floratos, Executive
Director, C2B2, floratos@c2b2.columbia.edu
, phone: 212-851-5139
Services
Tailored for Infectious Disease Research:
(List of
example services but not limited to)
•
Provide
informatics solutions for specific research
projects.
a) Integrate and analyze functional genomics and
proteomics data
b) Design microarray probe and analyze microarray
data
c) Model and analyze host-pathogen interactions
d) Model macromolecular structures and provide
therapeutic designs
e) Provide secure server facilities for storage
and analysis of sensitive pathogen or clinical
data (e.g., non-public pathogen genome)
f) Develop software to assist basic and
translational research in infectious disease
g) Facilitate experimental design and grant
applications that benefit from informatics
methods
h) Provide training and education to disseminate
informatics knowledge and skills
• Bioinformatics and
Computational Biology
a) Integrate, model and analyze
biological data modeling, analysis and mining;
b) Construct and maintain biological database
c) Develop scientific software tools
• Biomonitoring and Clinical
Informatics:
a) Monitor adverse events or emerging infectious
diseases
b) Manage electronic medical record
c) Model and mine clinical datasets
Previous
Management and Staff from 2003-2005:
• Yves A. Lussier, MD, PI, Director;
• Edward H. Shortliffe, MD, Ph.D, co-PI;
• Yang Liu, Ph.D, Ass. Dir.
• Hedi Hegyi, Ph.D, Post-Doctoral
Research Scientist
• Inderpal Kohli, Senior Analyst -
Programmer
Previous Co-investigators from 2003-2005:
• Jeffrey Skolnick, PhD, University of
Buffalo
• Mark Gerstein, PhD, Yale University
• Cornelia Büchen-Osmond, PhD, Columbia University
& ICTVdB
Resources from 2003-2005. The BIC builds on existing
infrastructure in the Columbia Laboratory for
Knowledge Technology (Lussier Research Group) of the Department of
Biomedical Informatics at Columbia University (DBMI), as well as the
infrastructures of the Gerstein Reseach Group of Yale University with
expertise in comparative and functional genomics
and the University of Buffalo Center of
Excellence in Bioinformatics (Skolnick Research Group), with expertise in prtein
function prediction. The BIC supports a wide
range of software for nucleic acid and protein
analyses, molecular modeling and statistical
analyses. In addition, the BIC has service
agreements with two groups provide additional
biomedical informatics services: the AMDeC Bioinformatics Core Facility at the Columbia
Genome Center and the Oncoinformatics core of the Herbert Irving
Comprehensive Cancer Center.
Columbia
University, New York, NY10032
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